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货号: PD4228
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类：
靶点: p130
应用： IF,ELISA
反应性 ： Human,Mouse,Rat
宿主物种 ： Rabbit
MW(CalcμLated) ： 128kD
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
推荐稀释比 ： IF 1:200-1:1000;ELISA 1:5000;Not yet tested in other applications;
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： p130 Polyclonal Antibody detects endogenous levels of p130 protein.
基因名称 ： RBL2
蛋白名称 ： Retinoblastoma-like protein 2
别名 ： RBL2;RB2;Retinoblastoma-like protein 2;130 kDa retinoblastoma-associated protein;p130;Retinoblastoma-related protein 2;RBR-2;pRb2
背景：
function:Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.,miscellaneous:G0-restricted expression.,PTM:During G0 and early G1 phase of the cell cycle, phosphorylated on Ser-639 and on 5 sites within the domain B. Phosphorylation on Ser-672 in G1 leads to its ubiquitin-dependent proteolysis.,similarity:Belongs to the retinoblastoma protein (RB) family.,subunit:Interacts with AATF. Interacts with SUV420H1 and SUV420H2 (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RINT1.,
细胞定位 ： Nucleus.
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