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N-Shc Polyclonal Antibody

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说明书下载
货号: PD4506
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: N-Shc
应用: IHC,IF,ELISA
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(Observed): 48kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : N-Shc Polyclonal Antibody detects endogenous levels of N-Shc protein.
基因名称 : SHC3
蛋白名称 : SHC-transforming protein 3
别名 : SHC3;NSHC;SHCC;SHC-transforming protein 3;Neuronal Shc;N-Shc;Protein Rai;SHC-transforming protein C;Src homology 2 domain-containing-transforming protein C3;SH2 domain protein C3

数据库链接:

Organism

基因 ID

SwissProt

背景:

function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.,PTM:Tyrosine phosphorylated.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors.,tissue specificity:Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.,

细胞定位 : cytosol,plasma membrane,

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