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推荐稀释比 ： WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:10000.
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： Nogo A Polyclonal Antibody detects endogenous levels of Nogo A protein.
基因名称 ： RTN4
蛋白名称 ： Reticulon-4
别名 ： RTN4;KIAA0886;NOGO;My043;SP1507;Reticulon-4;Foocen;Neurite outgrowth inhibitor;Nogo protein;Neuroendocrine-specific protein;NSP;Neuroendocrine-specific protein C homolog;RTN-x;Reticulon-5
背景：
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
细胞定位 ： [Isoform A]: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell membrane; Multi-pass membrane protein ; Cytoplasmic side . Anchored to the membrane of the endoplasmic reticulum (ER) through 2 putative transmembrane domains. Localizes throughout the ER tubular network (PubMed:27619977). Co-localizes with TMEM33 at the ER sheets. .; [Isoform B]: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein ; Extracellular side . Cell junction . Mainly located on endoplasmic reticulum tubules and sheet edges (PubMed:27786289). Upon ICAM1 engagement, redistributed toward endothelial junctions where interacts with CDH5 (PubMed:21183689). .; [Isoform C]: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
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