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货号: PD4889
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: mGluR-2/3
应用: WB,IHC,IF,ELISA
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(Observed): 100kD
同种型-Isotype : IgG
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal
抗原&靶点信息
特异性 : mGluR-2/3 Polyclonal Antibody detects endogenous levels of mGluR-2/3 protein.
基因名称 : GRM2
蛋白名称 : Metabotropic glutamate receptor 2
别名 : GRM2;GPRC1B;MGLUR2;Metabotropic glutamate receptor 2;mGluR2;GRM3;GPRC1C;MGLUR3;Metabotropic glutamate receptor 3;mGluR3
数据库链接:
Organism
基因 ID
SwissProt
Mouse
背景:
glutamate metabotropic receptor 2(GRM2) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene


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