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货号: PD5908
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: HAND1
应用： IHC,IF,ELISA
反应性 ： Human,Mouse,Rat
宿主物种 ： Rabbit
MW(CalcμLated) ： 24kD
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
推荐稀释比 ： IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： HAND1 Polyclonal Antibody detects endogenous levels of HAND1 protein.
基因名称 ： HAND1
蛋白名称 ： Heart- and neural crest derivatives-expressed protein 1
别名 ： HAND1;BHLHA27;EHAND;Heart- and neural crest derivatives-expressed protein 1;Class A basic helix-loop-helix protein 27;bHLHa27;Extraembryonic tissues;heart, autonomic nervous system and neural crest derivatives-expressed protein 1;eH
背景：
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008],
细胞定位 ： Nucleus, nucleoplasm . Nucleus, nucleolus . Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity). .
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