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AF-4 Polyclonal Antibody

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说明书下载
货号: PD7069
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: AF-4
应用: IHC,IF,WB,ELISA
反应性 : Human,Mouse
宿主物种 : Rabbit
MW(Observed): 130kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:500-2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : AF-4 Polyclonal Antibody detects endogenous levels of AF-4 protein.
基因名称 : AFF1
蛋白名称 : AF4/FMR2 family member 1
别名 : AFF1;AF4;FEL;MLLT2;PBM1;AF4/FMR2 family member 1;ALL1-fused gene from chromosome 4 protein;Protein AF-4;Protein FEL;Proto-oncogene AF4

数据库链接:

Organism

基因 ID

SwissProt

Mouse
背景:

This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in mu

细胞定位 : Nucleus .

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