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Retinoic Acid Receptor α/β (Phospho Ser96) rabbit pAb

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说明书下载
货号: PF0205
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: Retinoic Acid Receptor α/β
应用: WB
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(Observed): 50kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

修饰-Modification : Phospho
推荐稀释比 : WB 1:500-2000
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : This antibody detects endogenous levels of Retinoic Acid Receptor α/β (Phospho-Ser96) at Human, Mouse,Rat
基因名称 : RARA NR1B1
蛋白名称 : Retinoic Acid Receptor α/β (Phospho-Ser96)
别名 : Retinoic acid receptor alpha;RAR-alpha;Nuclear receptor subfamily 1 group B member 1;

数据库链接:

Organism

基因 ID

SwissProt

背景:

This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010],

细胞定位 : Nucleus . Cytoplasm . Nuclear localization depends on ligand binding, phosphorylation and sumoylation (PubMed:19850744). Translocation to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation (By similarity). Increased nuclear localization upon pulsatile shear stress (PubMed:28167758). .

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