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TOP2A (Phospho Ser1213) rabbit pAb

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货号: PF0375
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: TOP2A
应用: WB,ELISA
反应性 : Human,Rat,Mouse,
宿主物种 : Rabbit
MW(Observed): 174kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

修饰-Modification : Phospho
推荐稀释比 : WB 1:1000-2000;ELISA 1:5000-20000
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : This antibody detects endogenous levels of Human TOP2A (Phospho Ser1213)
基因名称 : TOP2A TOP2
蛋白名称 : TOP2A (Phospho Ser1213)
别名 : TOP2A;TOP2;DNA topoisomerase 2-alpha;DNA topoisomerase II;alpha isozyme

数据库链接:

Organism

基因 ID

SwissProt

背景:

catalytic activity:ATP-dependent breakage, passage and rejoining of double-stranded DNA.,enzyme regulation:Specifically inhibited by the intercalating agent amsacrine.,function:Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.,miscellaneous:Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.,PTM:Phosphorylation has no effect on catalytic activity.,similarity:Belongs to the type II topoisomerase family.,subcellular location:Generally located in the nucleoplasm.,subunit:Homodimer. Interacts with COPS5.,

细胞定位 : Cytoplasm . Nucleus, nucleoplasm . Nucleus . Nucleus, nucleolus .

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