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IL-8Rβ (phospho Ser347) Polyclonal Antibody

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货号: PF0982
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: IL-8Rβ
应用: WB,IHC,IF,ELISA
反应性 : Human,
宿主物种 : Rabbit
MW(Observed): 48kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

修饰-Modification : Phospho
推荐稀释比 : WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : Phospho-IL-8Rβ (S347) Polyclonal Antibody detects endogenous levels of IL-8Rβ protein only when phosphorylated at S347.
基因名称 : CXCR2
蛋白名称 : C-X-C chemokine receptor type 2
别名 : CXCR2;IL8RB;C-X-C chemokine receptor type 2;CXC-R2;CXCR-2;CDw128b;GRO/MGSA receptor;High affinity interleukin-8 receptor B;IL-8R B;IL-8 receptor type 2;CD antigen CD182

数据库链接:

Organism

基因 ID

SwissProt

背景:

C-X-C motif chemokine receptor 2(CXCR2) Homo sapiens The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as

细胞定位 : Cell membrane; Multi-pass membrane protein.

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