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Cdc6 (phospho Ser54) Polyclonal Antibody

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说明书下载
货号: PF1294
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: Cdc6
应用: WB,IHC,IF,ELISA
反应性 : Human,Mouse,Monkey
宿主物种 : Rabbit
MW(Observed): 62kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

修饰-Modification : Phospho
推荐稀释比 : WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : Phospho-Cdc6 (S54) Polyclonal Antibody detects endogenous levels of Cdc6 protein only when phosphorylated at S54.
基因名称 : CDC6
蛋白名称 : Cell division control protein 6 homolog
别名 : CDC6;CDC18L;Cell division control protein 6 homolog;CDC6-related protein;Cdc18-related protein;HsCdc18;p62;cdc6;HsCDC6

数据库链接:

Organism

基因 ID

SwissProt

背景:

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008],

细胞定位 : Nucleus . Cytoplasm . The protein is nuclear in G1 and cytoplasmic in S-phase cells (PubMed:9566895). .

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