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货号: PF1298
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: Abl1/2
应用： WB,IHC,IF,ELISA
反应性 ： Human,Mouse,Monkey
宿主物种 ： Rabbit
MW(Observed)： 125kD(200kD BCR-ABL complex）
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
修饰-Modification ： Phospho
推荐稀释比 ： WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： Phospho-Abl1/2 (Y393/439) Polyclonal Antibody detects endogenous levels of Abl1/2 protein only when phosphorylated at Y393/439.
基因名称 ： ABL1/ABL2
蛋白名称 ： Tyrosine-protein kinase ABL1/2
别名 ： ABL1;ABL;JTK7;Tyrosine-protein kinase ABL1;Abelson murine leukemia viral oncogene homolog 1;Abelson tyrosine-protein kinase 1;Proto-oncogene c-Abl;p150;ABL2;ABLL;ARG;Abelson tyrosine-protein kinase 2;Abelson murine leukemia vira
数据库链接：
背景：
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [pr
细胞定位 ： Cytoplasm, cytoskeleton. Nucleus. Mitochondrion . Shuttles between the nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative stress (By similarity). .; [Isoform IB]: Nucleus membrane; Lipid-anchor. The myristoylated c-ABL protein is reported to be nuclear.
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