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SH-PTP2 (phospho Tyr580) Polyclonal Antibody

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说明书下载
货号: PF1335
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560

详细信息

修饰-Modification : Phospho
推荐稀释比 : WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : Phospho-SH-PTP2 (Y580) Polyclonal Antibody detects endogenous levels of SH-PTP2 protein only when phosphorylated at Y580.
基因名称 : PTPN11
蛋白名称 : Tyrosine-protein phosphatase non-receptor type 11
别名 : PTPN11;PTP2C;SHPTP2;Tyrosine-protein phosphatase non-receptor type 11;Protein-tyrosine phosphatase 1D;PTP-1D;Protein-tyrosine phosphatase 2C;PTP-2C;SH-PTP2;SHP-2;Shp2;SH-PTP3

数据库链接:

Organism

基因 ID

SwissProt

背景:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016],

细胞定位 : Cytoplasm . Nucleus .

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