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修饰-Modification ： Phospho
推荐稀释比 ： WB 1:500-1:2000;ELISA 1:5000;Not yet tested in other applications.
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： Phospho-Claudin-7 (Y210) Polyclonal Antibody detects endogenous levels of Claudin-7 protein only when phosphorylated at Y210.
基因名称 ： CLDN7
蛋白名称 ： Claudin-7
别名 ： CEPTR L2;CEPTRL 2;CEPTRL2;Claudin 1;Claudin 7;Claudin 9;Claudin-7;Claudin1;Claudin7;Claudin9;CLD7_HUMAN;CLDN 7;CLDN-7;CLDN7;Clostridium perfringens enterotoxin receptor like 2;CPETR L2;CPETRL 2;CPETRL2;Hs.84359
背景：
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010],
细胞定位 ： Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane . Cell junction, tight junction . Co-localizes with EPCAM at the basolateral cell membrane and tight junction. .
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