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推荐稀释比 ： WB 1:500-1:2000;ELISA 1:20000;Not yet tested in other applications.
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： Cleaved-Cathepsin C HC (R394) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin C HC protein resulting from cleavage adjacent to R394.
基因名称 ： CTSC
蛋白名称 ： Dipeptidyl peptidase 1
别名 ： CTSC;CPPI;Dipeptidyl peptidase 1;Cathepsin C;Cathepsin J;Dipeptidyl peptidase I;DPP-I;DPPI;Dipeptidyl transferase
背景：
This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. [provided by RefSeq, Nov 2015],
细胞定位 ： Lysosome.
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