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MKP-4 (PT1683R) PT™ Rabbit mAb

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说明书下载
货号: PL0107
货期: 现货
价格: 100μL/1800
+


靶点: MKP-4
应用: WB,IHC,IF,ELISA
反应性 : Human
宿主物种 : Rabbit
MW(CalcμLated) : 42kD
MW(Observed): 42kD
同种型-Isotype : IgG,Kappa

隐藏域元素占位

详细信息

推荐稀释比 : IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein A
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆号 : Monoclonal

抗原&靶点信息

特异性 : Endogenous
基因名称 : DUSP9
蛋白名称 : Dual specificity protein phosphatase 9
别名 : DUSP9;MKP4;Dual specificity protein phosphatase 9;Mitogen-activated protein kinase phosphatase 4;MAP kinase phosphatase 4;MKP-4

数据库链接:

Organism

基因 ID

SwissProt

背景:

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progr

细胞定位 : Cytoplasm.

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