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TLR3 (PT1588R) PT™ Rabbit mAb

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说明书下载
货号: PL0189
货期: 现货
价格: 100μL/1800
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靶点: TLR3
应用: WB,IHC,IF,ELISA
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(CalcμLated) : 104kD
MW(Observed): 104kD
同种型-Isotype : IgG,Kappa

隐藏域元素占位

详细信息

推荐稀释比 : IHC 1:200-1:500;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein A
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆号 : Monoclonal

抗原&靶点信息

特异性 : Endogenous
基因名称 : TLR3
蛋白名称 : Toll-like receptor 3
别名 : CD283;CD283 antigen;IIAE2;TLR 3;Tlr3;TLR3_HUMAN;Toll Like Receptor 3;Toll-like receptor 3.

数据库链接:

Organism

基因 ID

SwissProt

背景:

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate

细胞定位 : Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Early endosome .

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