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Claudin 18.2 Rabbit mAb

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说明书下载
货号: PL0321
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: Claudin 18.2
应用: WB,IHC,IF,ELISA
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(CalcμLated) : 28kD
MW(Observed): 28kD
同种型-Isotype : IgG,Kappa

隐藏域元素占位

详细信息

推荐稀释比 : IHC 1:200-1:1000;WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein A
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆号 : Monoclonal

抗原&靶点信息

特异性 : Endogenous
基因名称 : CLDN18 UNQ778/PRO1572
蛋白名称 : Claudin-18
别名 : Claudin-18

数据库链接:

Organism

基因 ID

SwissProt

背景:

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010],

细胞定位 : Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein . Localizes to tight junctions in epithelial cells. .

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