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货号: PL0797
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: p70 S6 kinase α
应用： WB,IF,ELISA
反应性 ： Human,Mouse,Rat
宿主物种 ： Rabbit
MW(CalcμLated) ： 59kD
MW(Observed)： 70kD
同种型-Isotype ： IgG, Kappa
偶联-Conjugate ： Phospho
隐藏域元素占位
详细信息
修饰-Modification ： Thr389
推荐稀释比 ： WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成 ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 ： Protein A
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
克隆号 ： PT0721R
抗原&靶点信息
特异性 ： p70 S6 Kinase (Phospho Thr389) Monoclonal Antibody detects endogenous levels of Phospho Atm around the phosphorylation site of Thr389 protein.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):GFtYV
基因名称 ： RPS6KB1 STK14A P70S6K
蛋白名称 ： Ribosomal protein S6 kinase beta-1，p70 S6 Kinase (Thr389)
别名 ： RPS6KB1;STK14A;Ribosomal protein S6 kinase beta-1;S6K-beta-1;S6K1;70 kDa ribosomal protein S6 kinase 1;P70S6K1;p70-S6K 1;Ribosomal protein S6 kinase I;Serine/threonine-protein kinase 14A;p70 ribosomal S6 kinase alpha;p70 S6 kinas
背景：
ribosomal protein S6 kinase B1(RPS6KB1) Homo sapiens This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013],
细胞定位 ： Cell junction, synapse, synaptosome . Mitochondrion outer membrane. Mitochondrion. Colocalizes with URI1 at mitochondrion.; [Isoform Alpha I]: Nucleus. Cytoplasm.; [Isoform Alpha II]: Cytoplasm.
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