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xCT Rabbit mAb

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说明书下载
货号: PL1304
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: SLC7A11
应用: WB,IHC,IF,IP,ELISA
反应性 : Human,Mouse,Rat,
宿主物种 : Rabbit
MW(CalcμLated) : 37kD
MW(Observed): 55kD
同种型-Isotype : IgG,Kappa
偶联-Conjugate : Unmodified

隐藏域元素占位

详细信息

推荐稀释比 : IHC 1:200-1:1000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200,
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein A
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
克隆号 : PT0398R

抗原&靶点信息

特异性 : Endogenous
基因名称 : SLC7A11
蛋白名称 : Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT)
别名 : Cystine/glutamate transporter;Amino acid transport system xc-;Calcium channel blocker resistance protein CCBR1;Solute carrier family 7 member 11;xCT;

数据库链接:

Organism

基因 ID

SwissProt

背景:

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]

细胞定位 : Membrane

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