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货号: PL1392
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类:
靶点: Bcl-x
应用: WB,IHC,IF,IP,ELISA
反应性 : Human,Mouse,Rat,
宿主物种 : Rabbit
MW(CalcμLated) : 26kD
MW(Observed): 30kD
同种型-Isotype : IgG,Kappa
偶联-Conjugate : Unmodified
隐藏域元素占位
详细信息
推荐稀释比 : IHC 1:200-1:1000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200,
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein A
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
克隆号 : PT0244R
抗原&靶点信息
特异性 : Endogenous
基因名称 : BCL2L1
蛋白名称 : Bcl-2-like protein 1
别名 : BCL2L1;BCL2L;BCLX;Bcl-2-like protein 1;Bcl2-L-1;Apoptosis regulator Bcl-X
背景:
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015],


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