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货号: PF0801
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
靶点: MYLK
应用： IHC,IF,ELISA
反应性 ： Human,Rat,Mouse,
宿主物种 ： Rabbit
MW(CalcμLated) ： 211kD
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
修饰-Modification ： Phospho
推荐稀释比 ： IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： Phospho-MYLK (Y464) Polyclonal Antibody detects endogenous levels of MYLK protein only when phosphorylated at Y464.
基因名称 ： MYLK
蛋白名称 ： Myosin light chain kinase smooth muscle
别名 ： MYLK;MLCK;MLCK1;MYLK1;Myosin light chain kinase, smooth muscle;MLCK;smMLCK;Kinase-related protein;KRP;Telokin;[Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]
背景：
myosin light chain kinase(MYLK) Homo sapiens This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been
细胞定位 ： Cytoplasm . Cell projection, lamellipodium . Cleavage furrow . Cytoplasm, cytoskeleton, stress fiber . Localized to stress fibers during interphase and to the cleavage furrow during mitosis. .
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