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CHD8 Polyclonal Antibody

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说明书下载
货号: PG8117
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: CHD8
应用: IHC,IF
反应性 : Human,Rat,Mouse,
宿主物种 : Rabbit
MW(Observed): 283kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : IHC 1:50-300;IF 1:50-200
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : CHD8 Polyclonal Antibody detects endogenous levels of protein.
基因名称 : CHD8 HELSNF1 KIAA1564
蛋白名称 : Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1)

数据库链接:

Organism

基因 ID

SwissProt

Mouse
背景:

This gene encodes a DNA helicase that functions as a transcription repressor by remodeling chromatin structure. It binds beta-catenin and negatively regulates Wnt signaling pathway, which plays a pivotal role in vertebrate early development and morphogenesis. Mice lacking this gene exhibit early embryonic death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010],

细胞定位 : Nucleus . Localizes to the promoter regions of several CTNNB1-responsive genes. Also present at known CTCF target sites. .

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