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HUWE1 Polyclonal Antibody

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说明书下载
货号: PG6881
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: HUWE1
应用: IHC,IF
反应性 : Human,Mouse
宿主物种 : Rabbit
MW(Observed): 481kD
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : IHC 1:50-300;IF 1:50-200
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal

抗原&靶点信息

特异性 : HUWE1 Polyclonal Antibody detects endogenous levels of protein.
基因名称 : HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272
蛋白名称 : E3 ubiquitin-protein ligase HUWE1 (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)

数据库链接:

Organism

基因 ID

SwissProt

Mouse
背景:

This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation. [provided by RefSeq, Aug 2013],

细胞定位 : Cytoplasm . Nucleus . Mitochondrion . Mainly expressed in the cytoplasm of most tissues, except in the nucleus of spermatogonia, primary spermatocytes and neuronal cells (By similarity). Recruited to mitochondria following interaction with AMBRA1 (PubMed:30217973). .

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